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nordicbioscience胶原蛋白形成生物标志物
点击次数:77 发布时间:2020-11-24

 

nordicbioscience胶原蛋白形成生物标志物

 

Assay name

Assay description

Volume required (uL)

PRO-C1

Internal epitope in the N-terminal pro-peptide of type I collagen

50

PRO-C2

Released N-terminal pro-peptide of type II collagen

50

PRO-C3

Released N-terminal pro-peptide of type III collagen

50

PC3X

Cross-linked N-terminal pro-peptide of type III collagen

50

iP3NP

Internal epitope in the N-terminal pro-peptide of type III collagen

50

PRO-C4

Internal epitope in the 7S domain of type IV collagen

50

PRO-C5

Released C-terminal pro-peptide of type V collagen

50

PRO-C6

C-terminal of released C5 domain of type VI collagen α3 chain (endotrophin)

50

PRO-C8

C-terminal of type VIII collagen

50

PRO-C10

C-terminal of type X

50

PRO-C11

Released N-terminal pro-peptide of type XI collagen

50

PRO-C16

C-terminal of Type XVI collagen

50

PRO-C18

N-terminal type XVIII collagen

50

PRO-C18L

N-terminal of the type XVIII collagen medium and long isoforms

50

PRO-C19

C-terminal of type XIX collagen

50

PRO-C23

C-terminal of type XXIII collagen

50

PRO-C28

C-terminal of type XXVIII collagen

50

Collagen degradation biomarkers

Assay name

Assay description

Volume required (uL)

C1M

Neo-epitope of MMP-2,9,13 mediated degradation of type I collagen

50

C2M

Neo-epitope of MMP mediated degradation of type II collagen

80

T2CMNeo-epitope of MMP-1 and -13 mediated degradation of type II collagen50

C3M

Neo-epitope of MMP-9 mediated degradation of type III collagen

50

urine C3M

Neo-epitope of MMP-9 mediated degradation of type III collagen

50

C3A

Neo-epitope of ADAMTS-4,5 mediated degradation of type III collagen

50

C3C

Neo-epitope of cathepsin-B,L,S mediated degradation of type III collagen

50

C4M

Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 1 chain

50

C4Ma3

Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 3 chain

50

TUM

MMP-9 mediated release of tumstatin from type IV collagen alpha 3 chain

50

urine C4M

Neo-epitope of MMP-2,9,12 mediated degradation of type IV collagen alpha 1 chain

50

C4G

Neo-epitope of granzyme B mediated degradation of type IV collagen

50

C5M

Neo-epitope of MMP-2,9 mediated degradation of type V collagen

50

C6M

Neo-epitope of MMP-2 mediated degradation of type VI collagen

50

C6Ma3

Neo-epitope of MMP-9 mediated degradation of type VI collagen

50

C7M

Neo-epitope of type MMP-13 mediated decradation of type VII collagen

50

C10C

Neo-epitope of cathepsin-K mediated decradation of type X collagen

50

Col10NCNeo-epitope of the NC domain of type X collagen50
CTX-INeo-epitope of cathepsin mediated degradation of type I collagen50
CTX-II (Urine)

Neo-epitope of MMP mediated degradation of type II collagen

100
CTX-III

Cross-linked type III collagen C-terminal telopeptide

50

Elastin based biomarkers

Assay name

Assay description

Volume required (uL)

EL-CG

Neo-epitope of caghepsin G mediated degradation of elastin

50

ELM

Neo-epitope ('441) of MMP-9,12 mediated degradation of elastin

80

ELM12

Neo-epitope ('552) of MMP-9,12 mediated degradation of elastin

50

ELM7

Neo-epitope of MMP-7 mediated degradation of elastin

50

EL-NE

Neo-epitope of neutrophil elastase mediated degradation of elastin

50

ELP-3

 Neo-epitope of proteinase-3 mediated degradation of elastin 50

Wound healing biomarkers

Assay name

Assay description

Volume required (uL)

PRO-FIB

Neo-epitope of thrombin mediated degradation of fibrinogen

50

X-FIB

Neo-epitope of plasmin mediated degradation of cross-linked fibrin (sandwich assay)

80

FXIIIAP

Neo-epitope of thrombin mediated degradation of transglutaminase FXIII

50

vWF-A

Neo-epitope of ADAMTS13 mediated degradation of von willebrand factor

50

vWF-N

Released N-terminal pro-peptide of von willebrand factor

50

F1.2/F2

Neo-epitope of Fxa/Fva mediated degradation of prothrombin

50

F1

Neo-epitope of thrombin mediated degradation of prothrombin50

T-FIB

 

Neo-epitope of plasmin mediated degradation of fibrin

50

Extracellular matrix associated biomarkers

Assay name

Assay description

Volume required (uL)

a-SMA

Acetylated N-terminal of alpha-smooth muscle actin

50

BGM

Neo-epitope of MMP-9,12 mediated degradation of biglycan

50

DCN-CS

Cathepsin S mediated decorin degradation

50

HSP47-C

C-terminal of heat shock protein-47

50

LAM

Neo-epitope of MMP-9 mediated degradation of laminin alpha 5 chain

50

LG1M

Neo-epitope of MMP-9 mediated degradation of laminin gamma 1 chain

50

MIM

Neo-epitope of MMP-9,12 mediated degradation of mimecan

50

NIC

Neo-epitope of cathepsin-S mediated degradation of nidogen

50

SPARC-M

Neo-epitope of MMP mediated degracation of SPARC

50

TIM

Neo-epiotpe of MMP-12 mediated degradation of titin (Cardiac isoform)

50

TIM-2

Specific fragment of MMP-12-mediated degradation of titin (Muscle isoform)

50

VCANM

Neo-epitope of MMP-8,12 mediated degradation of versican

50

VICM

Neo- epitope of MMP-2, 8 and trypsin mediated degradation of citrullinated vimentin

50

ARGS

N-terminal epitope of Aggrecanase mediated degradation of aggrecan

50

FBN-C

C-terminal of fibronectin

 

50

CPa9-HNE

Neo-epitope fo human neutrophil elastase (HNE) mediated degradatib if calprotectin

 

50

PROM

Neo-epitope of MMP-1 and -13 mediated degradation of prolargin

50

uPerla

Neo-epiotpe of ADAMTS mediated degradation of perlecan

50

exAGNxI

Neo-epitope of aggrenase mediated aggrecan

50

exFFGV

Neo-epitope of MMP mediated aggrecan

50

BREM

Brevican degraded by MMPs

50

BREV-A

Neo-epitope of ADAMTS-4 mediated degradation of brevican

50

n-BREV

N-terminal of brevican

50

TAU-A

Neo-epitope of ADAM-10 mediated degradation of TAU

50

TAU-C

Neo-epitope of caspase-3 mediated degradation of TAU

50

exMMP3

Activated MMP-3

50

acCAT-K

Activated Cathepsin K

50

acMMP-9

Activated MMP-9

50

acMMP-13

N-terminal of active MMP-13

50

acADAMTS4

N-terminal of active ADAMTS-4

50

acADAMTS5

N-terminal of active ADAMTS-5

50

COMP-N

N-terminal of COMP

50

SPARC-C

C-terminal of SPARC

50

AGR-N

N-terminal of agrin

50

FBN-EDA

Neo-epitope of MMP-8 mediated degradation of cellular fibronectin (EDA domain)

50

FMODM

Fibromodulin degraded by MMP-12

50

Other biomarkers

Assay name

Assay description

Volume required (uL)

GDF-8

Myostatin (growth/differentiation factor 8)

150

IL-6

Interleukin-6

250

FMODM

Fibromodulin degraded by MMP-12

50

Ostase BAP

Bone-specific Alkaline Phosphatase ELISA

100

PIIANP

Type IIA Collagen N-Propeptide (PIIANP) ELISA

10

C-P-Tau (181P)

Phosphorylated Tau (P181)

50

C-β-Amyloid (1-42)

Amyloid Beta 1-42

50

HCG

Chorionic Gonadotropin (pregnancy test)

10

PTH, intact

Parathyroid hormone

50

S-Free T4

thyroxine

15

S-Testosterone

testosterone

20

S-Total T3

Total triiodothyronine

30

S-TSH

thyroid stimulating hormone

50

Total PINP

N-terminal pro-peptide of type I collagen

20

Anti-CCP

Anti-citrullinated protein antibodies

15

Anti-HCV

Antibodies to hepatitis C virus

50

HBsAg II

Hepatitis B surface antigen

50

HIV combi PT

HIV-1 P24 antigen, antibodies against HIV-1 and HIV-2

40

HIV-Ag

HIV-1 P24 antigen group M and O

50

Insulin

Insulin

20

S-Albumin

Albumin

2

S-ALAT

Alanine transaminase

25

S-ASAT

Aspartate transaminase

25

S-Bilirubin

Total billirubin

14.3

S-Calcium

Serum calcium

16

S-Cholesterol

Serum cholesterol

4

S-Creatinine

Serum creatinine

24

S-GGT

Gamma-glutamyltransferase

10

S-Glucose

Glucose

3.4

S-protein

Total serum protein

17.5

S-Urea

Serum urea

7

S-HDL Cholesterol

Serum HDL cholesterol

5

S-LDL Cholesterol

Serum LDL cholesterol

5

Urine Calcium

Urine calcium

16

Urine Creatinine

Urine Creatinine

24

Urine Phosphat

Urine Phosphat

8

S-Phosphat

Serum phosphat

8

S-Magnesium

Serum magnesium

12

S-Lipase

Serum lipase

3

S-Amylase

Serum amylase

16

S-LDH

Serum LDH

14

S-CO2

Serum CO2

6

ELF

 

65

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