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当前位置:首页 > 技术文章 > 澳大利亚Biosensis公司Fluoro-Jade B (FJB) 粉末用于识别退化神经元介绍

澳大利亚Biosensis公司Fluoro-Jade B (FJB) 粉末用于识别退化神经元介绍

更新时间:2025-10-15      点击次数:26

 一、基础信息  

货号:TR-150-FJB  

英文名:Fluoro-Jade B (FJB) Powder for Identifying Degenerating Neurons  

中文名:Fluoro-Jade B (FJB) 粉末用于识别退化神经元

规格:30 mg(干粉形式)  

品牌:Biosensis

分子式:C26H16O7  

分子量:448.4  

激发波长:495 nm  

发射波长:521 nm  

纯度检测:HPLC ≥95%  

荧光量子产率:0.85(相对荧光素)  

溶解性:易溶于水(pH 3.0-5.0)  

替代性说明:该产品为Merck-Millipore已停产产品AG310的替代品,性能与原产品高度一致。  

5fadb438a2a81d94f42314d4cf5317ac_fjb_image_2014_gao_f_1.png

 二、产品原理  

Fluoro-Jade B(FJB)是一种基于阴离子荧光素衍生物的神经组织学染色试剂,其核心原理是通过特异性结合退化神经元的脂质膜成分(如磷脂酰乙醇胺)实现荧光标记。具体机制包括:  

1. 靶向退化神经元:  

   - 在神经元变性过程中,细胞膜结构破坏导致脂质代谢产物(如磷脂酰乙醇胺)暴露,FJB通过静电作用与这些成分结合。  

   - 与正常神经元相比,退化神经元的膜电位改变进一步增强了FJB的渗透性和结合效率。  

2. 荧光信号触发:  

   - FJB的最大激发波长为495 nm(蓝光),发射波长为521 nm(绿色),可通过荧光显微镜或共聚焦显微镜观察。  

   - 染色后神经元呈现明亮的绿色荧光,背景干扰极低,适用于高分辨率成像。  

3. 抗干扰性:  

   - FJB无需金属沉积步骤(如传统镀银染色),避免了金属离子背景干扰。  

   - 对组织固定方式(甲醛、戊二醛等)和切片类型(冷冻、石蜡包埋)兼容性更强。  


 三、解决的核心实验问题  

1. 传统技术的局限性:  

   - 镀银染色法:需多步金属还原反应,耗时长达24小时以上,且成本高昂,难以实现多重标记。  

   - 免疫组化标记:依赖特异性抗体,仅能识别特定病理标志物(如Tau蛋白),无法全面反映神经元退化的整体情况。  

2. 神经退行性疾病研究的痛点:  

   - 早期病变检测:FJB可标记尚未出现明显形态学改变的早期退化神经元,为阿尔茨海默病、帕金森病等疾病的机制研究提供敏感工具。  

   - 多模型适用性:支持体外培养神经元(如原代皮层神经元)和体内模型(如大鼠海马区损伤模型)的退化评估。  

3. 胶质细胞标记需求:  

   - FJB不仅能标记神经元,还可特异性结合反应性星形胶质细胞,为神经炎症研究提供新视角。  


 四、产品优势  

1. 高灵敏度与特异性:  

   - 检测灵敏度可达单细胞水平,信噪比优于传统染色方法。  

   - 虽纯度略低于FJC(Biosensis另一产品),但成本仅为FJC的1/3,适合大规模实验。  

2. 实验兼容性广泛:  

   - 样本类型:支持冷冻切片、石蜡切片、培养细胞及灌注固定的组织样本。  

   - 联合染色:可与DAPI(细胞核标记)、GFAP(星形胶质细胞标记)或免疫荧光抗体(如Iba-1标记小胶质细胞)联用,实现多维度病理分析。  

3. 操作便捷性:  

   - 染色流程仅需3步:组织透化→FJB染色→封片,全程耗时约1小时。  

   - 工作液稳定性高,现配现用,避免储存降解风险。  

4. 经济性与可持续性:  

   - 单批次30 mg粉末可满足数百次染色需求(每次使用约1 μg),显著降低长期实验成本。  

   - 干粉形式减少运输和储存中的污染风险,符合实验室绿色化趋势。  


 五、客户群体  

1. 神经科学研究机构:  

   - 专注于阿尔茨海默病、帕金森病、肌侧索硬化症(ALS)等神经退行性疾病的实验室。  

   - 从事神经发育、神经代谢及神经免疫学研究的团队。  

2. 药企与CRO公司:  

   - 需评估药物对神经元保护作用的药理部门(如抗癫痫药物、神经保护剂开发)。  

   - 提供神经毒性评价服务的合同研究组织(CRO)。  

3. 教学与临床转化平台:  

   - 医学院校的神经生物学教学实验室,用于本科生/研究生实验教学。  

   - 医院病理科开展神经退行性疾病诊断辅助研究。  


 六、订货信息  

1. 购买渠道:  

   - 中国区代理:上海起发

2. 储存与使用注意事项:  

   - 干粉储存:避光保存于-20℃,避免吸潮;已溶解的0.01%原液建议4℃短期储存(不超过3个月)。  

   - 质量控制:每批次提供质检报告(包括纯度检测、荧光稳定性测试)。  

 八、常见问题解答(FAQ)  

1. Q:FJB能否用于活细胞染色?  

A:FJB需通过固定透化处理进入细胞,活细胞染色需特殊协议,建议优先使用终浓度≤1 μM的预处理方案。  

2. Q:与Nissl染色相比有何优势?  

A:Nissl染色反映细胞活性,而FJB特异性标记退化神经元,二者联用可区分坏死与凋亡。  

3. Q:如何避免染色背景过高?  

A:优化透化时间(推荐10-15分钟),避免过度消化;使用0.1% Triton X-100作为透化剂。  


九、总结  

Fluoro-Jade B(TR-150-FJB)作为神经退行性研究的核心工具,凭借其高灵敏度、实验灵活性和经济性,已成为全球3000余家实验室的优秀试剂。Biosensis公司通过持续优化生产工艺,确保产品性能稳定,而艾美捷科技凭借本土化服务网络,为中国科研用户提供从产品供应到技术支持的完整解决方案。无论是基础研究还是药物开发,FJB都为揭示神经元退化的分子机制提供了不可替代的技术支撑。


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