一、基础信息
货号:TR-150-FJB
英文名:Fluoro-Jade B (FJB) Powder for Identifying Degenerating Neurons
中文名:Fluoro-Jade B (FJB) 粉末用于识别退化神经元
规格:30 mg(干粉形式)
品牌:Biosensis
分子式:C26H16O7
分子量:448.4
激发波长:495 nm
发射波长:521 nm
纯度检测:HPLC ≥95%
荧光量子产率:0.85(相对荧光素)
溶解性:易溶于水(pH 3.0-5.0)
替代性说明:该产品为Merck-Millipore已停产产品AG310的替代品,性能与原产品高度一致。
二、产品原理
Fluoro-Jade B(FJB)是一种基于阴离子荧光素衍生物的神经组织学染色试剂,其核心原理是通过特异性结合退化神经元的脂质膜成分(如磷脂酰乙醇胺)实现荧光标记。具体机制包括:
1. 靶向退化神经元:
- 在神经元变性过程中,细胞膜结构破坏导致脂质代谢产物(如磷脂酰乙醇胺)暴露,FJB通过静电作用与这些成分结合。
- 与正常神经元相比,退化神经元的膜电位改变进一步增强了FJB的渗透性和结合效率。
2. 荧光信号触发:
- FJB的最大激发波长为495 nm(蓝光),发射波长为521 nm(绿色),可通过荧光显微镜或共聚焦显微镜观察。
- 染色后神经元呈现明亮的绿色荧光,背景干扰极低,适用于高分辨率成像。
3. 抗干扰性:
- FJB无需金属沉积步骤(如传统镀银染色),避免了金属离子背景干扰。
- 对组织固定方式(甲醛、戊二醛等)和切片类型(冷冻、石蜡包埋)兼容性更强。
三、解决的核心实验问题
1. 传统技术的局限性:
- 镀银染色法:需多步金属还原反应,耗时长达24小时以上,且成本高昂,难以实现多重标记。
- 免疫组化标记:依赖特异性抗体,仅能识别特定病理标志物(如Tau蛋白),无法全面反映神经元退化的整体情况。
2. 神经退行性疾病研究的痛点:
- 早期病变检测:FJB可标记尚未出现明显形态学改变的早期退化神经元,为阿尔茨海默病、帕金森病等疾病的机制研究提供敏感工具。
- 多模型适用性:支持体外培养神经元(如原代皮层神经元)和体内模型(如大鼠海马区损伤模型)的退化评估。
3. 胶质细胞标记需求:
- FJB不仅能标记神经元,还可特异性结合反应性星形胶质细胞,为神经炎症研究提供新视角。
四、产品优势
1. 高灵敏度与特异性:
- 检测灵敏度可达单细胞水平,信噪比优于传统染色方法。
- 虽纯度略低于FJC(Biosensis另一产品),但成本仅为FJC的1/3,适合大规模实验。
2. 实验兼容性广泛:
- 样本类型:支持冷冻切片、石蜡切片、培养细胞及灌注固定的组织样本。
- 联合染色:可与DAPI(细胞核标记)、GFAP(星形胶质细胞标记)或免疫荧光抗体(如Iba-1标记小胶质细胞)联用,实现多维度病理分析。
3. 操作便捷性:
- 染色流程仅需3步:组织透化→FJB染色→封片,全程耗时约1小时。
- 工作液稳定性高,现配现用,避免储存降解风险。
4. 经济性与可持续性:
- 单批次30 mg粉末可满足数百次染色需求(每次使用约1 μg),显著降低长期实验成本。
- 干粉形式减少运输和储存中的污染风险,符合实验室绿色化趋势。
五、客户群体
1. 神经科学研究机构:
- 专注于阿尔茨海默病、帕金森病、肌侧索硬化症(ALS)等神经退行性疾病的实验室。
- 从事神经发育、神经代谢及神经免疫学研究的团队。
2. 药企与CRO公司:
- 需评估药物对神经元保护作用的药理部门(如抗癫痫药物、神经保护剂开发)。
- 提供神经毒性评价服务的合同研究组织(CRO)。
3. 教学与临床转化平台:
- 医学院校的神经生物学教学实验室,用于本科生/研究生实验教学。
- 医院病理科开展神经退行性疾病诊断辅助研究。
六、订货信息
1. 购买渠道:
- 中国区代理:上海起发
2. 储存与使用注意事项:
- 干粉储存:避光保存于-20℃,避免吸潮;已溶解的0.01%原液建议4℃短期储存(不超过3个月)。
- 质量控制:每批次提供质检报告(包括纯度检测、荧光稳定性测试)。
八、常见问题解答(FAQ)
1. Q:FJB能否用于活细胞染色?
A:FJB需通过固定透化处理进入细胞,活细胞染色需特殊协议,建议优先使用终浓度≤1 μM的预处理方案。
2. Q:与Nissl染色相比有何优势?
A:Nissl染色反映细胞活性,而FJB特异性标记退化神经元,二者联用可区分坏死与凋亡。
3. Q:如何避免染色背景过高?
A:优化透化时间(推荐10-15分钟),避免过度消化;使用0.1% Triton X-100作为透化剂。
九、总结
Fluoro-Jade B(TR-150-FJB)作为神经退行性研究的核心工具,凭借其高灵敏度、实验灵活性和经济性,已成为全球3000余家实验室的优秀试剂。Biosensis公司通过持续优化生产工艺,确保产品性能稳定,而艾美捷科技凭借本土化服务网络,为中国科研用户提供从产品供应到技术支持的完整解决方案。无论是基础研究还是药物开发,FJB都为揭示神经元退化的分子机制提供了不可替代的技术支撑。
关键词:Biosensis、Biosensis神经科学抗体、Biosensis ELISA试剂盒、Biosensis组织染色试剂盒、Biosensis神经营养因子抗体、Biosensis退化神经元染色、Biosensis淀粉样斑块染色、Biosensis帕金森病研究抗体、Biosensis阿尔茨海默病研究试剂、Biosensis PDGF-AB ELISA试剂盒、Biosensis寡聚淀粉样βELISA试剂盒、Biosensis神经丝轻链抗体、Biosensis胶质细胞源性神经营养因子抗体、Biosensis脑源性神经营养因子ELISA、Biosensis神经生长因子受体ELISA、Biosensis离子钙结合接头分子1抗体、Biosensis双皮质素抗体、Biosensis帕金森病蛋白7抗体、Biosensis成熟NGF ELISA、Biosensis原NGF ELISA、Biosensis神经退行性疾病抗体、Biosensis自噬研究抗体、Biosensis代谢应激障碍试剂、Biosensis神经免疫学试剂、Biosensis炎症研究抗体、Biosensis中国代理、Biosensis神经科学产品线、Biosensis抗体应用WB/ICC/IHC
更多产品信息,请联系中国区域代理商:上海起发实验试剂有限公司
如果您对任意产品或其他品牌感兴趣,可通过“在线留言"功能留下您的需求
(注:本文内容基于品牌公开资料及行业常规信息整理,具体以品牌信息文档为准。)
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TR-100-FJT | Fluoro-Jade C (FJC) Ready-to-Dilute Staining Kit for identifying Degenerating Neurons (Trial size) | 20mL | Biosensis |
TR-100-FJ | Fluoro-Jade C (FJC) Ready-to-Dilute Staining Kit for identifying Degenerating Neurons | 40mL | Biosensis |
TR-150-FJB | Fluoro-Jade B (FJB) Powder for identifying Degenerating Neurons | 30mg | Biosensis |
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tr-300-ag | Amylo-Glo RTD Amyloid Plaque Stain Reagent | 5mL | Biosensis |
BEK-2211-1P | Mature BDNF Rapid ELISA Kit: Human, Mouse, Rat (1 plate) | 1PlateKit | Biosensis |
BEK-2215-1P | Oligomeric Amyloid-beta, Human, Rat, ELISA assay | 1PlateKit | Biosensis |
BEK-2244-1P | Bovine A2 Beta Casein ELISA Kit (1 plate) | 1PlateKit | Biosensis |
BEK-2233-2P | LR3IGF-I Rapid ELISA Kit: Human | 2PlateKit | Biosensis |
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TR-160-FJC | Fluoro-Jade C (FJC) Powder for identifying Degenerating Neurons-30 mg | 30mg | Biosensis |
PE-1831-20 | Casein, bovine beta A1, Purified Native Protein-20 µg | 20ug | Biosensis |
BEK-2215-2P | Oligomeric Amyloid-beta, Human, Rat, ELISA assay | 2PlateKit | Biosensis |
BEK-2233-1P | LR3IGF-I, Human, Rapid? ELISA assay-1 Plate Kit | 1PlateKit | Biosensis |
C-1780-100 | Chicken antibody to bovine A2 beta casein protein: Affinity purified | 100uL | Biosensis |
PE-1750-1000 | Oligomeric Human beta-Amyloid Abeta1-42 Peptide, Stabilized | 2x500ng | Biosensis |
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R-107-100 | Myelin basic protein (MBP), Rabbit Polyclonal Antibody-100 µL | 100uL | Biosensis |
BEK-2243-1P | A1 Beta casein (A1), Bovine, ELISA assay-1 Plate Kit | 1PlateKit | Biosensis |
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M-1818-100 | Mouse monoclonal antibody to human NGFR/p75NTR [8J2]: IgG | 100ug | Biosensis |
BEK-2217-2P | Brain-derived neurotrophic factor, pro- (proBDNF), Human, Mouse, Rat, Rapid™ ELISA assay-2 Plate Kit | 2PlateKit | Biosensis |
BEK-2217-1P | proBDNF Rapid ELISA Kit: Human, Mouse, Rat (1 Plate) | 1PlateKit | Biosensis |
BEK-2211-1P-CE | Brain-derived neurotrophic factor, mature (BDNF, mature), Human, CE-Marked ELISA assay-1 Plate Kit | 1PlateKit | Biosensis |
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M-1586-100 | Amyloid beta peptide (A-beta 40/42), Mouse Monoclonal Antibody-100 µg | 100ug | Biosensis |
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PE-019-100 | Nerve growth factor (2.5S), Mouse, Purified Native Protein-100 µg | 100ug | Biosensis |
PE-019-25 | Nerve growth factor (2.5S), Mouse, Purified Native Protein-25 µg | 25ug | Biosensis |
C-1386-50 | Neurofilament heavy polypeptide, phosphorylated, (pNF-H), Chicken Polyclonal Antibody- 50 µL | 50uL | Biosensis |
PE-019-500 | Mouse nerve growth factor (2.5S) protein | 500ug | Biosensis |
PE-1749-50 | Beta-Amyloid Abeta1-42 Peptide, HFIP-treated | 50ug | Biosensis |
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BEK-2212-1P | Nerve growth factor (Beta-NGF), Human, Rapid™ ELISA assay-1 Plate Kit | 1PlateKit | Biosensis |
BEK-2212-2P | Nerve growth factor (Beta-NGF), Human, Rapid™ ELISA assay-2 Plate Kit | 2PlateKit | Biosensis |
BEK-2213-1P | NGF Rapid ELISA Kit: Mouse (1 Plate) | 1PlateKit | Biosensis |
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BEK-2232-SET | Multi-Neurotrophin Screening, Rat, Rapid™ ELISA assay-4 x 6 Strips Set | 4x6StripsSet | Biosensis |
BEK-2239-1P | NGFR/p75ECD Rapid ELISA Kit: Human (1 Plate) | 1PlateKit | Biosensis |
BEK-2239-2P | NGFR/p75ECD Rapid ELISA Kit: Human (2 Plates) | 2PlateKit | Biosensis |
BEK-2240-SET | Mature BDNF/proBDNF Combo (BEK-2211/2217), Human, Mouse, Rat, Rapid™ ELISA assay-2 x 1 Plate Set | 2x1PlateSet | Biosensis |
BEK-2241-SET | Mature BDNF/proBDNF Combo (BEK-2211/2237), Human, Mouse, Rat, Rapid™ ELISA assay-2 x 1 Plate Set | 2x1PlateSet | Biosensis |
BEK-2244-10P | A2 Beta casein (A2), Bovine, ELISA assay | 10PlateKit | Biosensis |
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